RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-18a
RNA ID
RNA Type
miRNA
Alteration Pattern
phosphorylated perk and hnrnpa1
Species
homo sapiens
Detection Methods
grp78; immunoblottings; qRT-PCR etc.
Target
NA
Pathway
NA
PubMed ID
Title
Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2
Year
2016
Function
Brivanib reduces liver fibrosis in three different animal models and decreases human hepatic stellate cell activation. Brivanib may represent a novel therapeutic approach to treatment of liver fibrosis and prevention of liver cancer.